Twisted speaker cuts down on possible noise - DIYMA Car Audio ...

In theory: yes, because twisting makes sure all the noise induced will be induced to the negative and positive wire equally, cancelling out at the end...
This is how most balanced signal-cables are built and it actually helps...

But speaker-level signal is a LOT stronger than line-level, so the noise induced by the speaker-cables will be a lot less compared to line-signal cables when you compare it to the actual signal.
Result: it becomes inaudible (if it isn't, it's because you laid the speaker-wires next to something that gives a LOT of electromagnetical noise, meaning you'd better re-route the speakerwires).

I think twisting the speakerwires will have more effect on the noise *coming from* the speakerwires, than on the noise *induced by* them. I mean, if you put speakerwires that transfer very high power right next to insufficiently shielded RCA-cables, the RCA-cables might induce some unwanted electromagnetical noise from the speakerwires, which might me decreased when the speakerwires are twisted...

I doubt anyone would expect problems when using proper (not $100,-/ft treated with snake-oil, just normal good quality stuff) RCA-cables and carefully routing the cables.
A shielded main-power-cable will have a lot more influence, if any, when running a powerfull system and all wires (RCA, speaker, power) in just 1 bundle, but there are many people out there that do this without using shielded power-cable and have no problems at all...

Isabelle

Source: http://www.diymobileaudio.com/forum/car-audio-truth-myths-industry-dogma/138106-twisted-speaker-cuts-down-possible-noise.html

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